The hormone growth hormone (or somatotropin) is necessary for proper development and growth. Although it can have many health benefits, too much of this hormone could cause serious health problems. Learn more about the pros and cons of this hormone.
What is Growth Hormone?
Growth hormone (GH), also called somatotropin or somatotropin is a peptidehormone that stimulates growth and reduces body fat. It helps to maintain normal blood glucose levels. Here are some Best HGH Supplements to Boost Your HGH Levels Naturally.
The anterior pituitary, or brain region that synthesizes and secretes GH, is responsible for this. Two hormones are responsible for regulating GH secretion: GH-releasing hormone, GHRH, and somatostatin. GHRH stimulates the bloodstream’s release of GH, while somatostatin blocks it.
GH is released episodically. This hormone is secreted at all stages of life, and serves multiple functions beyond promoting growth.
Secretion of GH:
- It is low in childhood, but it increases slightly when you reach puberty.
- It is greatly increased in puberty and decreases in later adolescence.
- Stable until about 30 years of age.
- Gradually declines starting at 30 years of age.
- Role of Growth Hormones in Growth. GH can stimulate IGF-1 directly or indirectly.
Released GH travels through the bloodstream from the anterior pituitary to the liver, cartilages, and to the liver. It binds to the growth hormone receptor (GHR) which triggers the release of insulin-like factors 1 (IGF-1). To simulate normal growth, both GH and IGF-1 must be present.
GH is a growth hormone that acts on the growth plate to promote cell differentiation and growth. It stimulates bone cell proliferation and increases bone mass.
It increases muscle amino acid transport to increase fiber growth and distribution.
GH is a hormone that increases fat tissue’s ability to break down and mobilize fat.
1) Increase muscle mass and strength
A clinical trial with 13 healthy men between 50 and 70 showed that GH stimulated collagen synthesis within the tendons, muscles, and resulting in increased strength.
Another study on 16 healthy subjects over 60 years showed that GH increased protein synthesis and muscle strength in a second trial.
This is why athletes and bodybuilders often use GH to enhance their performance.
People with GH deficiencies, on the other hand, tend to have lower muscle mass and strength than those with normal levels.
Acromegaly refers to a condition that is caused by an excessive amount of GH. Acromegaly is a condition where a person has large muscles but not enough strength. This is due to an imbalance in the muscle composition that reduces power output.
2) Increase bone mass
GH plays a crucial role in bone growth during childhood, both in terms of length and mass. GH deficiencies have been linked to decreased bone mineral density and increased risk of fractures.
Therapy with GH can increase bone mineral density and decrease the risk of fractures in those who are deficient in this hormone.
3) May Increase Metabolism
The basal metabolic rate (BMR) is the amount of energy that is consumed at rest. GH can increase this. A small study on 7 people showed that GH deficiencies were accompanied by low basal metabolic rate (BMR). This could be corrected by supplying hormones. GH can also reduce body fat and increase fat-free mass.
4) May Lower Body Fat
In a clinical study on 24 obese subjects, GH supplementation led to an increase in fat breakdown.
Children and adults who are deficient in GH have more fat accumulation, particularly in the stomach. GH supplementation can help burn these fats and redistribute them throughout the body.
5) May Lower Blood Fat Levels
A study on mice showed that GH reduced blood triglyceride levels and cholesterol.
A study of 31 individuals with a genetic condition that causes “bad” LDL cholesterol levels to be very high (familial Hypercholesterolemia) showed that GH supplementation slightly lowered LDL.
6) May Improve Fertility
GH plays a role in fertility regulation and has been used to treat infertility, particularly in women.
The pituitary gland also produces GH. It is combined with GHRH and IGF-1, which increases the sensitivity to gonadotropin stimulation.
GH aids in follicular development and supplementation is one method of ovarian stimulation in assisted reproduction technologies. In select cases, GH has been shown in some cases to increase the likelihood of pregnancy.
The activity of aromatase, 3-b-hydrogenase, and aromatase is also enhanced by GH. This increases the conversion of androgen to estrogens in females. This is achieved via a direct or IGF-I-mediated mechanism. The maturation of the egg and follicle is affected by IGF-1, IGF-1, IGF-2.
7) May improve wound healing
A clinical trial with 46 children who had suffered from large burns found that supplementation with GH improved the rate of tissue healing and wound healing.
GH was also found to be beneficial in patients with severe injuries and bone fractures.
8) May Improve Heart Performance
GH improved the performance of the left ventricle of rats. This increased blood flow throughout the body, and reduced the chance of developing heart failure. This hormone also reduced blood vessel resistance, increasing blood flow and oxygen availability.
9) May regulate the Immune System
Multiple effects of GH on the immune system are possible. It promotes the proliferation of white blood cell and regulates antibody production by B and thymulin secretion from the thymus.
However, GH deficiency does not seem to have a significant impact on the immune system. It’s not associated to immunodeficiency in humans and has been linked to minor impairments in immune function.
Acromegaly is a condition where GH secretion is excessive, mostly due to benign tumors in pituitary gland. Acromegaly can be described as skeletal abnormalities such as jaw overgrowth, skull expansion and eyebrow bulging, soft tissue swelling (resulting from enlargements of the hands, feet and nose, ears and other organs), thick, rough and oily skin.
Patients with Acromegalic also experience severe headaches
A study of almost 58,000 people who had received GH therapy revealed that headaches and dizziness were common side effects.
3) Vision Disturbances
Acromegaly can sometimes cause blurred vision and complete blindness. These symptoms may be caused by an increase in the thickness of your retina.
Hypoglycemia is a condition in which blood glucose levels are low. This causes GH secretion to increase. Its effects are counter to insulin’s, leading to insulin resistance and high blood sugar levels.
Pathological conditions of GH excess can lead to increased glucose production, decreased muscle glucose intake, and higher blood glucose levels. This increases the risk of developing type 2 diabetes.
A small clinical trial with 8 patients treated with GH for short bowel disease revealed that all patients experienced swelling in the lower limbs.
6) Joint and Muscle Pain
The genetic disorder of joint hypermobility syndrome affects the joints, causing pain and exhaustion. A study of 31 patients with this condition and matched controls showed that joint and muscle pain was linked to high blood GH levels.
7) Sleep Apnea
Two studies of over 200 children who received GH therapy showed that sleep apnea can occur side effects.
Due to its ability to stimulate the growth of cells, GH has been shown to be able to cause cancer. A couple developed skin cancer after using topical GH to combat wrinkles.
However, there has not been any evidence to suggest a relationship between GH levels and the risk of developing cancer.